Pulse transit time changes in subjects exhibiting sleep disordered breathing
Chakrabarti B, Emegbo S, Craig S, Duffy N, O’Reilly J. Pulse transit time changes in subjects exhibiting sleep disordered breathing. Respir Med. 2017;122. Introduction Pulse Transit Time (PTT) represents a non-invasive marker of sleep fragmentation in OSAS. Little is known regarding PTT in sleepy subjects exhibiting nocturnal Inspiratory Flow Limitation (IFL) in the absence of apneas or desaturation. Materials and methods The IFL cohort was gender and age matched to subjects with OSAS and a cohort where Sleep ... Read More
Effect of CPAP on cardiac function in minimally symptomatic patients with OSA: Results from a subset of the MOSAIC randomized trial
Craig et al. Effect of CPAP on cardiac function in minimally symptomatic patients with OSA: Results from a subset of the MOSAIC randomized trial. J Clin Sleep Med [Internet]. 2015;11(9):967–73. Study Objectives Minimally symptomatic obstructive sleep apnea (OSA) is highly prevalent, and the effects of continuous positive airway pressure (CPAP) on myocardial function in these patients are unknown. The MOSAIC randomized, controlled trial of CPAP for minimally symptomatic OSA assessed the effect of CPAP on myocardial function in ... Read More
Markers of inflammation: Data from the MOSAIC randomised trial of CPAP for minimally symptomatic OSA
Stradling JR, Craig SE, Kohler M, Nicoll D, Ayers L, Nunn AJ, et al. Markers of inflammation: Data from the MOSAIC randomised trial of CPAP for minimally symptomatic OSA. Thorax. 2015;70(2):181–2. The Multi-centre Obstructive Sleep Apnoea Interventional Cardiovascular (MOSAIC) trial compared 6 months of CPAP therapy, versus no CPAP, in 391 patients with minimally symptomatic obstructive sleep apnoea (OSA). We now report some exploratory outcomes, markers of systemic inflammation (interleukin 6 (IL-6), IL-10, C reactive protein, tumour necrosis factor). We ... Read More
Continuous positive airway pressure improves sleepiness but not calculated vascular risk in patients with minimally symptomatic obstructive sleep apnoea: the MOSAIC randomised controlled trial
Craig SE, Kohler M, Nicoll D, et al Continuous positive airway pressure improves sleepiness but not calculated vascular risk in patients with minimally symptomatic obstructive sleep apnoea: the MOSAIC randomised controlled trial; Thorax 2012;67:1090-1096. Background Continuous positive airway pressure (CPAP) for symptomatic obstructive sleep apnoea (OSA) improves sleepiness and reduces vascular risk, but such treatment for the more prevalent, minimally symptomatic disease is contentious. Methods This multicentre, randomised controlled, parallel, hospital-based trial across the UK and Canada, recruited ... Read More
Implementation of a computer-guided consultation in the assessment of suspected obstructive sleep apnoea syndrome
Biswajit Chakrabarti, Nadia Lewis-Burke, Mike Pearson, Sonya Craig, Lisa Davies, Kim Sheridan, Philip England, Eddie McKnight, Robert Angus ERJ Open Research 2020 6: 00362-2019; DOI: 10.1183/23120541.00362-2019 The study reports the results of the use of the LungHealth Sleep guided consultation in the hands of both sleep medicine trained specialists and non-specialists when assessing consecutive unselected referrals with suspected Obstructive Sleep Apnoea. We evaluated the diagnostic accuracy of the software and compared this to the diagnosis made by a ... Read More
